Xinnan Wang Lab

Welcome to the Xinnan Wang Lab

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Mitochondria move and undergo fission and fusion in all eukaryotic cells. The accurate allocation of mitochondria in neurons is particularly critical due to the significance of mitochondria for ATP supply, Ca++ homeostasis and apoptosis and the importance of these functions to the distal extremities of neurons. In addition, defective mitochondria, which can be highly deleterious to a cell because of their output of reactive oxygen species, need to be repaired by fusing with healthy mitochondria or cleared from the cell. Thus mitochondrial cell biology poses critical questions for all cells, but especially for neurons: how the cell sets up an adequate distribution of the organelle; how it sustains mitochondria in the periphery; and how mitochondria are removed after damage. The goal of our research at the Xinnan Wang Lab is to understand the regulatory mechanisms controlling mitochondrial dynamics and function and the mechanisms by which even subtle perturbations of these processes may contribute to neurodegenerative disorders.

Research Support:

  • NINDS Research Project Grant (Parent R01)
  • NIH Pathway to Independence (K99/R00)
  • William and Bernice E. Bumpus Foundation Innovation Award
  • Alfred P. Sloan Research Fellowship
  • Gabilan Junior Faculty Fellowship
  • Michael J. Fox Foundation
  • Klingenstein Fellowship in Neuroscience
  • Calfiornia Institute for Regenerative Medicine
  • Chronic Fatigue Initiative
  • Shurl and Kay Curci Foundation

We welcome highly motivated postdoctoral fellows and graduate students!

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