Xinnan Wang Lab

Welcome to the Xinnan Wang Lab

Atossa15.03.12

Mitochondria move and undergo fission and fusion in all eukaryotic cells. The accurate allocation of mitochondria in neurons is particularly critical due to the significance of mitochondria for ATP supply, Ca++ homeostasis and apoptosis and the importance of these functions to the distal extremities of neurons. In addition, defective mitochondria, which can be highly deleterious to a cell because of their output of reactive oxygen species, need to be repaired by fusing with healthy mitochondria or cleared from the cell. Thus mitochondrial cell biology poses critical questions for all cells, but especially for neurons: how the cell sets up an adequate distribution of the organelle; how it sustains mitochondria in the periphery; and how mitochondria are removed after damage. The goal of our research at the Xinnan Wang Lab is to understand the regulatory mechanisms controlling mitochondrial dynamics and function and the mechanisms by which even subtle perturbations of these processes may contribute to neurodegenerative disorders.

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Honors & Awards:

  • Department of Defense
  • NINDS Research Project Grant (Parent R01)
  • The Archer Award
  • Biology V, Calfiornia Institute for Regenerative Medicine
  • Klingenstein Fellowship in Neuroscience
  • Alfred P. Sloan Research Fellowship
  • Gabilan Junior Faculty Fellowship, Stanford University
  • Mechanisms of Illness, Chronic Fatigue Initiative
  • Michael J. Fox Foundation Grant Target Validation Spring 2013
  • William and Bernice E. Bumpus Foundation Innovation Award
  • NIH Pathway to Independence (K99/R00), NINDS
  • Shurl and Kay Curci Foundation

We welcome highly motivated postdoctoral fellows and graduate students!

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